Rhodoliths are calcareous red algae considered indicators of ocean acidification and key biodiversity hotspots due to their ability to host a variety of species within their three-dimensional structures. This work aims to review the available scientific literature on rhodolith-forming species: reports from literature, the Symbiota digital taxonomic inventory, field observations, and nucleotide databases. A total of 21 species is reported, predominantly from the Corallinaceae family and the Lithophylloideae subfamily. Rhodoliths have been reported in Bocas del Toro, the Gulf of Chiriqui, Coiba National Park (PNC), the Gulf of Panama, and at the Las Perlas Archipelago. This review represents the first step in raising awareness about the presence of these organisms along Panama’s coast and advocating for their inclusion in the management plans of protected areas, such as PNC, a UNESCO World Heritage Site, where rhodoliths are not yet part of the recorded algae species list or the park’s conservation targets, despite their ecological relevance. Knowledge remains limited, and their conservation status is uncertain, but the increasing sampling efforts and integration of morphological and molecular studies will open new opportunities to improve the estimation of rhodolith diversity in Panama.

Abstract High-harmonic generation (HHG) is a highly nonlinear optical process that typically requires an intense laser to trigger emissions at integer multiples of the driving field frequency. Since HHG is commonly used as a spectroscopic tool to probe material properties, it becomes impossible to extract information about a material without introducing distortions caused by the strong driving field. Recent advances in bright squeezed vacuum sources have allowed HHG to be driven by purely quantum fields alone. Our work focuses on controlling and tuning HHG emission using a weak classical driving field with energy 1000 times less than that used in conventional HHG experiments, perturbed by an even weaker quantum field, such as bright squeezed vacuum (BSV). Our technique opens new avenues for nonlinear spectroscopy of materials by minimizing issues such as laser-induced damage, distortions, and heating. Our results show that a BSV pulse, containing less than ~0.5% of the driving laser energy, can serve as an optical dial for tuning nonlinear emission, electron dynamics, and ionization.

Abstract Centromeres are essential for chromosome function, yet their role in shaping genome evolution in polyploid plants, together with their highly variable forms across angiosperms, remains unresolved in the context of plant diversification. Allopolyploidy, in which post-hybridization genome doubling merges parental genomes that may differ markedly in chromosomal architecture, has the potential to increase centromeric complexity and influence genomic plasticity. We explore this possibility in carnivorous Caryophyllales, a morphologically and chromosomally diverse plant lineage that includes sundews, Venus flytraps, and Nepenthes pitcher plants. Focusing on sundews (Drosera), we generated chromosome-scale assemblies of holocentric D. regia and monocentric D. capensis, which share an allohexaploid origin but have diverged dramatically in genome structure. D. regia retains ancestral chromosomal fusions, dispersed centromeric repeats, and conserved synteny, whereas D. capensis exhibits extensive chromosomal reorganization and regionally localized centromeres following a lineage-specific genome duplication. Phylogenomic evidence traces D. regia to an ancient hybridization between sundew-like and Venus flytrap-like ancestors, setting it apart within its infrageneric context. Genus-wide repetitive DNA profiling reveals rapid turnover and species-level variation in centromere organization. Together, these results establish sundews as a natural system for investigating how centromere dynamics interact with recurrent polyploidization and episodes of ecological innovation to shape genomic resilience.

Abstract The large physical size of optical imaging systems is one of the greatest constraints on their use, limiting the performance and deployment of a range of systems from telescopes to mobile phone cameras. Spaceplates are nonlocal optical devices that compress free-space propagation into a shorter distance, paving the way for more compact optical systems, potentially even thin flat cameras. Here, we demonstrate the first engineered optical spaceplate and experimentally observe the highest space compression ratios yet demonstrated in any wavelength region, up to R=176±14, which is 29 times higher than any previous device. Our spaceplate is a multilayer stack, a well-established commercial fabrication technology that supports mass production. The versatility of these stacks allows for the freedom to customize the spaceplate's bandwidth and angular range, impossible with previous optical experimental spaceplates, which were made of bulk materials. With the appropriate choice of these two parameters, multilayer spaceplates have near-term applications in light detection and ranging (LIDAR) technologies, retinal scanners, endoscopes, and other size-constrained optical devices.

The third Critical Assessment of Computational Hit-finding Experiments (CACHE) challenged computational teams to identify chemically novel ligands targeting the macrodomain 1 of SARS-CoV-2 Nsp3, a promising coronavirus drug target. Twenty-three groups deployed diverse design strategies to collectively select 1739 ligand candidates. While over 85% of the designed molecules were chemically novel, the best experimentally confirmed hits were structurally similar to previously published compounds. Confirming a trend observed in CACHE #1 and #2, two of the best-performing workflows used compounds selected by physics-based computational screening methods to train machine learning models able to rapidly screen large chemical libraries, while four others used exclusively physics-based approaches. Three pharmacophore searches and one fragment growing strategy were also part of the seven winning workflows. While active molecules discovered by CACHE #3 participants largely mimicked the adenine ring of the endogenous substrate, ADP-ribose, preserving the canonical chemotype commonly observed in previously reported Nsp3-Mac1 ligands, they still provide novel structure-activity relationship insights that may inform the development of future antivirals. Collectively, these results show that multiple molecular design strategies can efficiently converge on similar effective molecules.

Abstract Starting in the 1830s, French musicians began to fully engage with the concept of nostalgia as an affective category and as a musical trait. The deliberate artistic process of naming music and musical works as ‘nostalgia’ contributed to the demedicalization of the term while transforming its original meaning as homesickness into a spectrum of spatiotemporal emotions. Musical renditions of nostalgia also displaced expressions and discussions of this emotion away from the countryside, where it had originally been rooted, towards the city. Musicians thus directly participated in the transformation of nostalgia into a commodity, a fashionable product that could be purchased in music stores, experienced firsthand in entertainment venues, and tailored to the needs and desires of an urban population. This article traces the shift in the evocation of nostalgia in music and the musical press during the nineteenth century in Paris, where it became most prevalent in dozens of vocal romances and instrumental pieces. The compositions that I analyse, rather than forming a unified depiction of the city, offer a range of sonorous and thematic ideas that provide a more comprehensive understanding of the place nostalgia played in the imagination of an urban population increasingly conscious of its artistic value and impact. I thus uncover three main stages in this shift, which show how successive generations of musicians, influenced by different attitudes to urbanity, conceived nostalgia. I investigate why composers drawn to nostalgia were attracted to certain types of musical and formal models, what these choices reveal about their understanding of nostalgia and its purpose, and, more importantly, what this musical nostalgia sounded like. This article provides the first overview of works that deliberately use nostalgia as an explicit topic across genres and generations in nineteenth-century Paris.

ABSTRACT Sport coaches can facilitate positive youth development in athletes. However, little is known about how coach behaviors that span the full range leadership model (i.e. FRLM) impact development. In this study, we asked whether FRLM coaching behaviors promote positive development outcomes and mitigate negative experiences in the university sport context and whether these effects are mediated by perceptions of a quality coach-athlete relationship. In total, 605 Canadian university athletes (Mage = 20.09 SD = 1.74) completed the Multifactor Leadership Questionnaire, the University Sport Experience Survey, and the Coach-Athlete Relationship Questionnaire. Mediation analyses assessed the explanatory role of athletes’ perceived coach-athlete relationship in associations between coaches’ leadership behaviors and athletes’ reports of personal developmental outcomes and negative experiences. The coach-athlete relationship was positively associated with positive development outcomes in university athletes (i.e. initiative, basic skills, interpersonal relationships, teamwork and social skills, and adult network and social capital) and inversely associated with negative experiences (i.e. stress, negative peer interactions, social exclusion, and negative leadership). Findings only partially supported the assertion that transformational leadership promotes positive development and reduces negative experiences by enhancing the coach-athlete relationship. The results support benefits of transformational coaching when targeting positive development, similar to youth sport, but suggest the coach-athlete relationship has little explanatory value when examining associations between coach leadership and positive development outcomes in university sport. Instead, the coach-athlete relationship does help account for the mitigation of negative experiences in the university sport context.