Although many bacterial species are vital to human healthand areimportant in the food industry, some species lead to disease, whichhas promoted the development of antibacterial agents to reduce infectionand illness. However, antibiotics can be toxic and increase bacterialresistance. Recently, we synthesized new silane-phosphonium monomersto form cross-linked thin coatings on polypropylene films. The producedsilica-phosphonium coatings act as antibiofilm and antiviral agents.Here, we prepared and characterized poly­(silane-phosphonium) nanoparticles(NPs) by a modified Stöber polymerization process and characterizedthem by scanning electron microscopy (SEM), dynamic light scattering(DLS), zeta (ζ) potential, X-ray photoelectron spectroscopy(XPS), and Fourier-transform infrared (FTIR) spectroscopy. These newlyformed NPs illustrate great potential in inhibiting Staphylococcus aureus (S. aureus), Listeria innocua (L. innocua), Escherichia coli (E. coli), Pseudomonasaeruginosa (P. aeruginosa), and the tomato brown rugose fruit virus (ToBRFV). These NPs aretoxic to mammalian cells but may have potential use for a varietyof agricultural, environmental, and medical applications, as discussedin the article.

Low-density lipoproteinreceptor (LDLR), which serves as one ofthe most major entry receptors for many viruses in both human andmouse cells, plays a vital role in virus infection. However, thereare no effective small molecules available to inhibit LDLR expressionand exhibit antiviral effects. Here, we screened Bruceine A (BA),a natural product derived from the major constituents in Brucea javanica(L.) Merr. whichinhibited vesicular stomatitis virus (VSV) infection in vitro. Mechanistically, BA blocked viral adsorption and internalization,facilitating antiviral effects through lysosome-mediated degradationof LDLR. Genetic knockdown of Ldlr exhibited strongantiviral effects. To the best of our knowledge, BA is the first LDLR-selectiveinhibitor, and our findings reveal that BA may serve as a potent andbroad-spectrum virus entry inhibitor based on LDLR entry receptor.