Malaria is a major public health problem. An effective vaccine against malaria is actively being sought. We formulate a potential outcomes definition of the efficacy of a malaria vaccine for preventing fever. A challenge in estimating this efficacy is that there is no sure way to determine whether a fever was caused by malaria. We study the properties of two approaches for estimating efficacy: (1) use a deterministic case definition of a malaria caused fever as the conjunction of fever and parasite density above a certain cutoff; (2) use a probabilistic case definition in which the probability that each fever was caused by malaria is estimated. We compare these approaches in a simulation study and find that both approaches can potentially have large biases. We suggest a strategy for choosing an estimator based on the investigator's prior knowledge about the area in which the trial is being conducted and the range of vaccine efficacies over which the investigator would like the estimator to have good properties.

The mobility of malaria-infected individuals poses challenges to elimination campaigns by way of spreading parasite drug resistance, straining country-to-country collaboration, and making routine data collection difficult, especially in resource-poor settings. Nevertheless, no concerted effort has been made to develop a common framework to define the spatial and temporal components of an imported malaria case and recommend the minimum data needed to identify it. We conducted a scoping review of imported malaria literature from 2010 to 2020 which showed that definitions vary widely, and local capabilities of detecting importation are often restricted in low-income countries. Following this, we propose a common definition for imported malaria and the minimum data required to identify a case, depending on the country’s capability of conducting an epidemiological investigation. Lastly, we utilize the proposed definition using data from Brazil to demonstrate both the feasibility and the importance of tracking imported cases. The case of Brazil highlights the capabilities of regular surveillance systems to monitor importation, but also the need to regularly use these data for informing local responses. Supporting countries to use regularly collected data and adopt a common definition is paramount to tackling the importation of malaria cases and achieving elimination goals set forth by the World Health Organization.

Periodic temporal variations in peripheral blood parasite density were evaluated in a simple parallel study of symptomatic young men and women in an endemic village in eastern Nigeria. Our main objective was to find the effect of chronobiology, on malaria definition and parasitaemia. Parasite densities were recorded four square times in each study subject at four hours interval. A total of fifty-one subjects with signs and symptoms suggestive of malaria were enrolled. Amplitude of variations of more than ten times was observed between the four hour interval. Results showed that frequent negative smears were observed mainly in the morning and evening hours while the highest parasite densities occurred at noon. Results further showed that there was significant difference between the parasite densities observed around noon and morning or evening period. Profiles of individual parasite densities are presented. These variations which are probably due to sequestration-release mechanism or any other mechanisms remain to be elucidated. Keywords : Chronobiology, Circadian, Cryptochrome, Sequestration.

Malaria is a disease transmitted by the bite of the female Anopheles mosquito and caused by protozoa of the genus Plasmodium. Malaria infection has several manifestations with cerebral malaria (CM) being the most severe neurological complication and a leading cause of malaria death. Cerebral malaria is characterized by a coma at least 1 hour after a seizure or a hypoglycemia, asexual forms of Plasmodium falciparum on peripheral blood smears, with the absence of any other causes of coma. This definition is quite vague in practice, thus making an accurate identification of clinical characteristics of cerebral malaria necessary in diagnosis to help reducing malaria deaths. This article is to summarize the medical literature to clarify the clinical characteristics of cerebral malaria.

Malaria is one of the most common treatable and preventable infectious diseases in the world; and 300–500 million malaria cases occur annually, leading to 1.5–2.7 million deaths in tropical countries. About one-third of these cases occur in Asia. In hyperendemic area, most of the children acquire infection by the age of 5 years. Children younger than 6 months enjoy immunity from their mothers. In India the disease occurs in all the agegroups. Most clinicians would consider any manifestation of cerebral dysfunction in a patient with malaria as cerebral malaria. These manifestations include impairment of consciousness (confusion, delirium, obtundation, stupor, or coma), convulsions, focal neurologic deficit, and psychosis. These abnormalities can as well be due to hypoglycemia or high fever only. Hence a precise definition has been recommended, which has been summarized in Box 1. Box 1 Definition of cerebral malaria Practical definition

Severe malaria caused by Plasmodium vivax is no longer considered rare. To describe its clinical features, we performed a retrospective case control study in the subregion of Luciano Castillo Colonna, Piura, Peru, an area with nearly exclusive vivax malaria transmission. Severe cases and the subset of critically ill cases were compared with a random set of uncomplicated malaria cases (1:4). Between 2008 and 2009, 6,502 malaria cases were reported, including 106 hospitalized cases, 81 of which fit the World Health Organization definition for severe malaria. Of these 81 individuals, 28 individuals were critically ill (0.4%, 95% confidence interval = 0.2-0.6%) with severe anemia (57%), shock (25%), lung injury (21%), acute renal failure (14%), or cerebral malaria (11%). Two potentially malaria-related deaths occurred. Compared with uncomplicated cases, individuals critically ill were older (38 versus 26 years old, P < 0.001), but similar in other regards. Severe vivax malaria monoinfection with critical illness is more common than previously thought.

The study assessed aspects of malaria infection, prevention and treatment in a population of resettled pregnant women in South Sudan. During April and May 2008, a cross-sectional study was carried out to estimate malaria prevalence and to assess the use of malaria risk reduction measures and their associations with selected background characteristics. Two hundred and twenty women were tested for malaria parasitaemia and questioned about their malaria prevention and treatment practices. The results showed a prevalence of Plasmodium falciparum parasitaemia of 9.1%. No statistically significant associations were observed between selected background characteristics and malaria infection status. However, school attendance was significantly associated with insecticide-treated net ownership (OR = 6.52, 95% CI 2.37-17.94; p = 0.001) and access to malaria diagnosis and treatment (OR = 3.20, 95% CI 1.26-8.16; p = 0.015). The results suggest that educational attainment need not be very advanced to affect practices of malaria prevention and treatment. Primary school attendance was a stronger predictor for use of malaria risk reduction measures than any of the other selected background characteristics. Educational attainment, information and communication about malaria prevention and control play a pivotal role in increasing and improving use of malaria risk reduction measures.

Malaria is the most common vector-borne parasitic infection causing significant human morbidity and mortality in nearly 90 tropical/sub-tropical countries worldwide. Significant differences exist in the incidence of malaria cases, dominant Plasmodium species, drug-resistant strains and mortality rates in different countries. Six Gulf Cooperation Council (GCC) countries (Bahrain, Kuwait, Qatar, Oman, Saudi Arabia and United Arab Emirates, UAE) in the Middle East region with similar climates, population demographics and economic prosperity are aiming to achieve malaria elimination. In this narrative review, all studies indexed in PubMed describing epidemiological characteristics of indigenous and imported malaria cases, vector control status and how malaria infections can be controlled to achieve malaria elimination in GCC countries were reviewed and discussed. These studies have shown that indigenous malaria cases are absent in Bahrain, Kuwait, Qatar and UAE and have progressively declined in Oman and Saudi Arabia. However, imported malaria cases continue to occur as GCC countries have large expatriate populations originating from malaria-endemic countries. Various malaria control and prevention strategies adopted by GCC countries including more stringent measures to reduce the likelihood of importing malaria cases by prior screening of newly arriving expatriates and vector elimination programs are likely to lead to malaria elimination in this region.

Asymptomatic malaria infections are highly prevalent in malaria endemic regions and most of these infections remain undiagnosed and untreated. Whereas conventional malaria symptoms are by definition absent, little is known on the more subtle health consequences of these infections. The aim of our study was to analyze the hematologic, vascular and inflammatory effects of patent and subpatent asymptomatic malaria parasitemia in children and adults on the Indonesian island Sumba. Both children and adults with parasitemia had increased high-sensitive C-reactive protein levels compared to aparasitemic individuals. In addition, children, but not adults with parasitemia also had lower platelet counts and Hb levels and higher levels of von Willebrand factor and platelet factor-4, markers of endothelial and platelet activation, respectively. These findings suggest that asymptomatic malaria infections have subtle health consequences, especially in children, and should be regarded as potentially harmful.

While hyperparasitemia is considered an important indicator for the development of severe malaria, there is currently no consensus on the quantitative definition of hyperparasitemia. This study was conducted to establish a cutoff point for peripheral parasitemia among patients with Plasmodium falciparum malaria, to define severe malaria. The clinical presentations of 200 uncomplicated P. falciparum malaria, and 189 severe P. falciparum malaria, patients, admitted to the Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, were analyzed. A peripheral parasitemia of 0.5% was found to be the optimal cutoff point for defining severe malaria, demonstrating highest sensitivity (85.1%), specificity (62.0%), and accuracy (73.2%). Symptoms of severe falciparum malaria depend on many factors. For the definition of hyperparasitemia in areas of low or seasonal transmission, peripheral parasitemia of 0.5% might be considered a cutoff point for discrimination between severity levels. This value might be useful for the clinical management of malaria, particularly in hypo-endemic areas, unstable transmission areas, and other areas with similar transmission patterns.