Genetic and biological factors role in dysmenorrhea

Answer from top 10 papers

The role of genetic and biological factors in dysmenorrhea is suggested by several studies, although direct genetic links are not extensively detailed in the provided contexts. For instance, Komariah et al. (2024) identifies a family history of dysmenorrhea as a risk factor for more severe menstrual pain, implying a potential genetic predisposition to the condition. Additionally, Kapadi and Elander (2019) explores the concept of hyperalgesia in women with primary dysmenorrhea, indicating that these women have an increased sensitivity to pain, which could be underpinned by biological differences in pain perception or modulation.
Interestingly, while genetic and biological underpinnings are hinted at, the papers primarily focus on psychosocial factors, symptom management, and the impact of dysmenorrhea on quality of life. For example, Evans et al. (2021) highlights the psychological mechanism of pain catastrophizing in women with menstrual pain, regardless of the underlying etiology, suggesting that cognitive and emotional responses to pain are significant. Iacovides et al. (2013) further supports this by showing that pain acceptance, rather than coping strategies or analgesic use, predicts better quality of life in women with primary dysmenorrhea.
In summary, while the provided papers do not delve deeply into the genetic and biological factors of dysmenorrhea, they do suggest that such factors may contribute to the condition, as evidenced by the association with family history and altered pain sensitivity (Kapadi & Elander, 2019; Komariah et al., 2024). However, the emphasis of the research appears to be on the psychosocial aspects and the management of symptoms, indicating a multifaceted approach to understanding and addressing dysmenorrhea. Further research is needed to elucidate the specific genetic and biological mechanisms at play in dysmenorrhea.

Source Papers

The association of dysmenorrhea with noncyclic pelvic pain accounting for psychological factors

The factors that underlie pelvic pain are poorly understood. Specifically, the relative influence of dysmenorrhea and psychological factors in the etiology of noncyclic pelvic pain conditions, such as interstitial cystitis and irritable bowel syndrome, is unknown. To further characterize pelvic pain, we compared the frequency of menstrual, somatosensory, and psychological risk factors between women with and without severe noncyclic pelvic pain symptoms. A total of 1012 reproductive-aged women completed a 112-item questionnaire with domains including mood, fatigue, physical activity, somatic complaint, and pain. Questionnaire items included existing items for menstrual distress and newly written items derived from qualitative interviews. The relationship of dysmenorrhea and noncyclic pelvic pain complaints (dyspareunia, dyschezia, or dysuria) was modeled using quantile regression. Among women who menstruate regularly, those with dysmenorrhea had disproportionally more severe noncyclic pelvic pain (54/402, 13%) than women without dysmenorrhea (5/432, 1%; odds ratio, 13; 95% confidence interval, 5-33). In a multivariate-adjusted model, dysmenorrhea (β = .17), activity capability (β = .17), somatic complaint (β = .17), and bodily pain (β = .12) were the primary predictors of noncyclic pelvic pain. Depression (β = .03) and anxiety (β = .01) were not significantly predictive. The presence of dysmenorrhea, somatic complaint, and low activity capability predicted 90% of the cases of women with noncyclic pelvic pain. The association between dysmenorrhea and noncyclic pelvic pain suggests that menstrual pain is an etiological factor in noncyclic pelvic pain, whereas depression and anxiety may be secondary effects. Longitudinal studies are needed to determine whether dysmenorrhea causally influences development of noncyclic pelvic pain or shares common underlying neural mechanisms.

Effect Of Chocolate and Exercise on Reducing Menstrual Pain (Dysmenorrhea) In Adolescent

Background: The problem of adolescent reproductive health is still a problem that needs attention. Many women experiences discomfort at the onset of menstruation, one of which is dysmenorrhea. Various attempts were made to relieve these symptoms is by acts of non-pharmacological such as exercise and giving chocolates. Purpose of this study was to determine the effect of the combination of chocolate and exercise to decrease menstrual pain (dysmenorrhea) in adolescents in SMPN 1 Bangkalan
 Methods: This method uses a method Quasi Experiment using a control time series design. The population in this study were students of SMP Negeri 1 Bangkalan who experienced dysmenorrhea. The sampling technique used in this study was simple random sampling with inclusion and exclusion criteria of 54 respondents who were divided into two groups with 27 respondents in each group.
 Results: The results showed that there was an effect of exercise and chocolate on decreasing menstrual pain with a sig value of 0.050 0.05 and an OR value of 5.263. In addition, there are also other factors that influence the decrease in menstrual pain, namely BMI with a sig value of 0.032 0.05 and an OR value of 0.214.
 Conclusion: there is an effect between the combination of exercise and chocolate in reducing menstrual pain (dysmenorrhea).

Pain coping, pain acceptance and analgesic use as predictors of health-related quality of life among women with primary dysmenorrhea

ObjectivesPrimary dysmenorrhea causes menstrual pain that affects women’s quality of life (QoL) and analgesics are only moderately effective. Pain coping and pain acceptance influence QoL among people affected by other chronic pain conditions, so we examined pain coping, pain acceptance and analgesic use as predictors of QoL among women with primary dysmenorrhea. Study design145 women with primary dysmenorrhea completed an online survey including the Menstrual Symptoms Questionnaire (MSQ), the Coping Strategies Questionnaire (CSQ), the Chronic Pain Acceptance Questionnaire (CPAQ-8), questions about analgesic use, and the Short Form-12 (SF-12), a measure of physical and mental health-related QoL. ResultsIn multiple regression, pain acceptance predicted better physical and mental QoL, whereas pain coping did not predict mental or physical quality of life. Being married or cohabiting and menstrual pain that was less severe and shorter in duration predicted better physical QoL, and those effects were mediated by pain acceptance. Being older at the onset of painful periods predicted better mental QoL and that effect was also mediated by pain acceptance. More severe menstrual pain and congestive rather than spasmodic dysmenorrhea predicted worse mental QoL but those effects were not mediated by other factors. Analgesic use did not predict physical or mental QoL. ConclusionsThe results show the impact that menstrual pain has on women’s quality of life, and suggest that initiatives to increase pain acceptance among women with menstrual pain are worthwhile. More research is needed to understand more fully the factors that influence health-related quality of life among women with menstrual pain.

Open Access
Auricular acupressure to improve menstrual pain and menstrual distress and heart rate variability for primary dysmenorrhea in youth with stress.

Background. Dysmenorrhea and accompanying symptoms can have a negative impact on academic achievement, physical activity and functioning, and quality of life. Unfortunately, stress increases the sensitivity and severity of pain, activating sympathetic responses while inhibiting parasympathetic responses. Objective. This study used objective, physiological measurements to evaluate the effects of auricular acupressure on menstrual pain and menstrual distress in young college students with primary dysmenorrhea across two menstrual cycles. The aim was to determine if significant differences could be detected between the intervention and follow-up phases after controlling life stress. Design. A one-group experimental research design was used, and repeated measurements and followups were done. Thirty-two women completed questionnaires and physiological parameters were measured. Results. Significant differences between the intervention and follow-up phases were found for high frequency (HF) and blood pressure on day 1 and no significant differences in menstrual pain and menstrual distress, heart rate variability, low frequency (LF), LF/HF ratio, or heart rate. Conclusion. Auricular acupressure effectively increases parasympathetic activity to maintain autonomic function homeostasis in young women with primary dysmenorrhea and may have a value in alleviating menstrual pain and menstrual distress in a high-stress life. Future studies should consider stress, stimulus dose of auricular acupressure, severity of menstrual pain, and a longitudinal research design.

Open Access
Period pain presenteeism: investigating associations of working while experiencing dysmenorrhea

Although menstrual pain (dysmenorrhea) is common and can have detrimental effects on work and social functioning, little is known about how people manage it in their professional life. Existing evidence indicates that people with dysmenorrhea often engage in presenteeism, meaning they work despite experiencing symptoms and report perceptions of social stigma around menstruation. In this study, we investigated individual health-related factors, psychosocial factors, and work factors associated with period pain presenteeism in a cross-sectional survey study including N = 668 employed people with experiences of dysmenorrhea. Our results show that symptom severity, disclosure of menstrual pain to the leader, and remote work are directly associated with period pain presenteeism. We further found that the presence of medical diagnosis moderates the association between symptom severity and presenteeism. Disclosure to the leader was associated with leader gender, leader-member exchange (LMX), and the absence of a medical diagnosis, indicating a potential mediating effect. We did not, however, find the perceptions of public beliefs regarding the concealment of menstruation to be related to presenteeism or disclosure. Our findings have important implications for research on menstrual health and occupational health management practice.

Open Access
Women With Dysmenorrhea Are Hypersensitive to Experimental Deep Muscle Pain Across the Menstrual Cycle

Primary dysmenorrhea is a common painful condition in women that recurs every month across the reproductive years. The recurrent nociceptive input into the central nervous system that occurs during menstruation each month in women with dysmenorrhea is hypothesized to lead to increased sensitivity to painful stimuli. We investigated whether women with primary dysmenorrhea are hyperalgesic to deep muscle pain induced by a cleanly nociceptive method of hypertonic saline injection. Pain stimulation was applied both within an area of referred menstrual pain (lower back) and at a remote site outside of referred menstrual pain (forearm) in 12 healthy women with severe dysmenorrhea and 9 healthy women without dysmenorrhea, at 3 phases of the menstrual cycle: menstruation and follicular and luteal phases. Women rated their pain severity on a 100-mm visual analog scale every 30 seconds after injection until the pain subsided. In both groups of women, menstrual cycle phase had no effect on the reported intensity and duration of muscle pain. However, women with dysmenorrhea had increased sensitivity to experimental muscle pain both at the site of referred pain and at a remote nonpainful site, as assessed by peak pain severity visual analog scale rating, area under the visual analog scale curve, and pain duration, compared to women without dysmenorrhea. These data show that women with severe primary dysmenorrhea, who experience monthly menstrual pain, are hyperalgesic to deep muscle pain compared to women without dysmenorrhea. PerspectiveOur findings that dysmenorrheic women are hyperalgesic to a clinically relevant, deep muscle pain in areas within and outside of referred menstrual pain indicates lasting changes in pain sensitivity outside of the painful period during menstruation.