Zmiany w układzie krążenia u pacjentów z toczniem rumieniowatym układowym

Abstract

Systemic lupus erythematosus (SLE) is a systemic chronic, inflammatory, autoimmune disease, characterized by various clinical manifestations and production of multiple autoantibodies. Complex immune system dysfunctions as well as chronic inflammatory processes lead to internal organs and tissue failure. The most common cardiovascular manifestations among patients with SLE include accelerated coronary heart disease, pericarditis, myocarditis, valvular disease, Libman–Sacks nonbacterial endocarditis - the most characteristic cardiac manifestation of the SLE, conduction abnormalities, pulmonary hypertension, thromboembolic events, hypertension and heart failure. Accelerated atherosclerosis with coronary heart disease is of key importance for prognosis, particularly among young women. An increased risk of cardiovascular events among patients with SLE has been confirmed in multiple studies. Getting closer to understanding multiple mechanisms of cardiovascular disease and pathogenesis of atherosclerosis in SLE is critical to lower mortality rate in this group population. The aim of this article is to present aetiology and cardiovascular manifestations processes of SLE.