Abstract
The influence of endotoxin treatment on iron and zinc absorption from the small intestine in normal and anemic rats is described. At the dose given in this study no significant changes in zinc absorption were observed. No decrease of iron absorption was found in anemic rats after endotoxin treatment, whereas iron absorption was decreased in normal rats. In the mucosa of anemic as well as of normal rats newly absorbed iron was shifted to the cytosol fraction in endotoxin treated animals. This is mainly due to an increase in ferritin binding. Hypothetical reasons for this change are discussed.
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