Abstract
Nowadays, cobalt isotopes 55Co, 57Co, and 58mCo are considered to be promising radionuclides in nuclear medicine, with 55Co receiving the most attention as an isotope for diagnostics by positron emission tomography. One of the current research directions is dedicated to its production using electron accelerators (via photonuclear method). In our work, the yields of nuclear reactions occurring during the irradiation of natNi and 60Ni by bremsstrahlung photons with energy up to 55 MeV were determined. A method of fast and simple cobalt isotopes separation from irradiated targets using extraction chromatography was developed.
Highlights
Two main methods for producing radioisotopes or their generators for nuclear medicine are widely used today: in nuclear reactors and cyclotrons
At the dawn of nuclear medicine, it was reported that 55Co complexes could be used for the diagnostics of lung cancer and for the visualization of tumors [2,3,4]
It is important to mention that the chemical properties of 55Co(II) and its behavior in an organism are similar to that of positron emission tomography (PET)-isotope 64Cu(II) (T1/2 = 12.7 h, 17.4% β+, Emaxβ+ = 653 keV) and of Ca(II), the latter being present in body but lacking suitable radioactive isotopes for its visualization [8,9,10]
Summary
Two main methods for producing radioisotopes or their generators for nuclear medicine are widely used today: in nuclear reactors and cyclotrons. Another possible way of their production is photonuclear method. It is important to mention that the chemical properties of 55Co(II) and its behavior in an organism are similar to that of PET-isotope 64Cu(II) (T1/2 = 12.7 h, 17.4% β+, Emaxβ+ = 653 keV) and of Ca(II), the latter being present in body but lacking suitable radioactive isotopes for its visualization [8,9,10]. In comparison to 64Cu(II), 55Co has the following advantages: first, compounds labeled with 55Co tend to be absorbed less by the Molecules 2022, 27, 1524 radioactive isotopes for its visualization [8,9,10]. Upsaitniegn5t5sCwoiitnh PtrEaTumasaatinc ibnrdaiicnationrjuorfycaanlcdiutmo easlltoimwastoenneetuorovnisauladliazme athgee awffiethctesdtrotiksesus eanind pbartaieinnttsuwmiotrhst[r1a1u–m13a]t.icAbsrfaoinr ointhjuerrymaenddictaoleisstoitmopatees noefuCroo,n5a8lmdCaom(Tag1/2e=w9i.t0h4shtr)oikseAs uangder bermaiinttteurmanodrst[h1u1s–1is3]s.uAitsafboler ofothreAr umgeedritchael riasoptyo,paensdof57CCoo, (5T8m1/2C=o2(7T11./82 d=, 9E.0γ 4=h1)2i2s kAeuVg)eirs esmuiittatebrleanfodrthpurescilsinsiucaitlabrelesefaorrcAh uagnedr tthheerastpuyd, yanodf 5p7hCaorm(Ta1c/o2 k=in2e7t1ic.8s do,fEdγru=g1s22bakseeVd) oisn scuoibtaabltledfoureptroectlhineiclaolnrgesehaarlcfh-liafendotfhtehsitsudisyotoofppehaarnmdatchoekinheigtihcsyoifedldruogfs pbarosedducoendcogbaamltdmuae-tqoutahnetalo[n1g4]h. alf-life of this isotope and the high yield of produced gamma-quanta [14]
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