Abstract
Neuroscience Patients with Parkinson's disease experience progressive loss of dopaminergic neurons and motor control. Zhang et al. found that the transcriptional cofactor YAP promoted dopaminergic neuronal survival in mice. YAP was activated upon binding of the extracellular matrix protein laminin-511 to an integrin. YAP then transcriptionally activated differentiation factors and a microRNA that decreased the levels of the apoptotic protein PTEN. These findings uncover a previously unknown role for YAP in neurons and a pathway that could promote dopaminergic neuronal survival in patients with Parkinson's disease. Sci. Signal. 10 , eaal4165 (2017).
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