Abstract
A screening test method for human blood-clotting Factor XIII was devised in which agglutination of Factor XIII-coated latex particles by its specific antibody is specifically inhibited by the Factor XIII contained in the test material. The antigenicity is absent in human serum, but is well retained in its activation process.Decrease in Factor XIII antigenic level was observed in liver diseases, cancer and post-operative cases. The results in latex agglutination inhibition test were generally in agreement with the Factor XIII activity in MDC incorporation or fibrin clot lysis tests as well as with the results of rocket immunoelectrophoresis. An attempt was made to devise latex agglutination test by coating latex particles with IgG fraction isolated from specific anti-subunit A serum.
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