Abstract
Objectives: 1. Determination of the percentage of Aspergillus species isolated in patients with invasive lung fungal infections at Bach Mai Hospital from July 2020 to June 2021; 2. Determination of susceptibility to antifungal drugs of isolated pathogenic Aspergillus strains.. Method: We conducted a cross-sectional study. 97 Aspergillus strains isolated from patients diagnosed with invasive lung fungal infections at Bach Mai Hospital from July 2020 to June 2021. Result: Aspergillus species isolated in patients with invasive lung fungal infections were mainly Aspergillus fumigatus (92.8%), and Aspergillus flavus (7.2%). The susceptibility rate to Asspergillus fumigatus of Voriconazole was 98.9%, Itraconazole was 100% and Posaconazole was 100%. The sensitivity rate of Itraconazole, Voriconazole and Posaconazole to Aspergillus flavus is 100%. The rate of resistance to Amphotericin B of Aspergillus fumigatus was 94.4%, of Aspergillus flavus was 85.1%. Conclusion: Aspergillus strains isolated in patients with invasive lung fungal infections at Bach Mai Hospital were frequently encountered with Aspergillus fumigatus and Aspergillus flavus. All strains of Aspergillus spp. Both are sensitive to Itraconazole and Posaconazole. Rate of resistance to Amphotericin B of Aspergillus spp. is very high. Keywords: Aspergillus spp., antifungal drug sensitivity
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