Abstract
Xanthomatous cells have lipid droplets in their cytoplasm. They may be associated with xanthomas that are cutaneous lesions of variable morphology, due to deposition of lipids in the skin. These deposits are inside histiocytes, which acquire a frothy appearance. They can be associated with disturbance of lipid metabolism, especially hyperlipemia and hypercholesterolemia. A female patient, white, 59 years old, presented with a submucosal lesion in the lower lip, approximately 2 cm, with purplish coloration of yellowish background, with no precise limits and with 2 years of evolution. The lesion was removed, and the patient was referred for histopathologic analysis in which sheets of foamy-looking histiocytes (xanthomatous cells) present in connective tissue and permeating muscle fibers and adipose tissue were observed. Immunohistochemistry was performed, with positivity for CD68 antigen and negativity for CD1a and protein S100. The patient is under medical investigation of metabolic syndrome that may be associated with the presence of these cells.
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