Abstract
The studies were made on a series of rats with foreign bodies placed in the bladder and the incidence of calculous formation was observed by polarizing microscope and, moreover, the same experiments were made on rabbits and analyzed by X-ray diffraction.The influence of glucuronic acid upon calculous formation was also studied on rats.(1) Struvite (MgNH4PO4·6H2O) was observed alone when the fragment of magnesium ammonium phosphate was used as nucleus. When calcium oxalate was used as nucleus, the components of the foreign bodies stones and all other daughter stones were Newberyite. And also, on the cases of uric acid stones, all of them were dissolved, but Newberyite were produced in a few samples.(2) Calcite was the main component on rabbits vesical calculi, but Struvite was also observed on the case of silk gut nucleus.(3) The formation of foreign bodies calculi of bladder in rats was prevented by the administration of glucuronic acid, but no effective influences could be expected on human urinary calculi which were used as nuclei.
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