WS12‐03Uteroplacental resistances and maternal cardiac function in normal and hypertensive pregnancy: a Doppler and echocardiographic study

Abstract

ObjectiveTo verify the existence of a relationship between maternal cardiac function and peripheral hemodynamic parameters in normal and gestational hypertensive women.Methods43 normotensive primigravidae were evaluated at 12 ± 1, 21 ± 1, and 33 ± 1 weeks of gestation with uterine artery color Doppler and maternal echocardiographic examination comparing data of the third trimester with those of 21 gestational hypertensive women.ResultsThe 43 healthy women showed a decrease in Uterine Resistance Index (RI) from I° to II° trimester (0.72 ± 0.10 vs. 0.54 ± 0.09, P < 0.001) and modifications in Diastolic function parameters: E wave velocity and E/A ratio decreased; A wave velocity and deceleration time of the E wave increased; the left ventricular isovolumetric relaxation time (IVRT) decreased significantly (88.7 ± 6.7, 75.6 ± 7.7, 71.1 ± 5.0 msec, P < 0.001) showing a correlation with left atrial dimensions and RI (r = −0.38, r = 0.47, P < 0.001). In the third trimester the comparison between normal and hypertensive women showed a significant reduction in (TVR) total vascular resistances (1006 ± 212 vs. 1620 ± 469, P = 0.000) and IVRT (71 ± 5.0 vs. 92.0 ± 7.6 msec, P = 0.000). Regression analysis showed a linear correlation between IVRT and TVR (r = 0.68; P < 0.01), Uterine RI and TVR were directly related (r = 0.59, P < 0.001).ConclusionsMaternal diastolic function analysis may be useful to identify women who fully adapt to pregnancy and at risk for development of gestational hypertension.