Abstract
The pharmacological activity of crude methanol extracts of Gliricidia maculata leaves were studied in the excision and granuloma wound models in rats. The rate of contraction was 86.65% ± 9.1% in treated compared with 92.43% ± 2.9% in control groups and the epithelialization time was prolonged to 20.2 ± 3.9 days in treated compared with 17.2 ± 0.9 days in control groups. Similarly, granuloma formation was not inhibited but disruption of endothelial cells and neovascularization was observed in the haemorrhaged granulomas. The low tensile strength in the excision wound was due to a low level of hydroxyproline 22.43 ± 9.9 µg/g tissue with a turnover of 19.05% ± 6.6% collagen compared with original levels of 32.44 ± 6.4 µg/g tissue of hydroxyproline and 24.20% ± 4.8% collagen. In the granuloma model, significant differences were observed in the treated group with 43.88 ± 6.8 µg/g tissue hydroxyproline and 61.88 ± 2.5 µg/g tissue in the control. Copyright © 1998 John Wiley & Sons, Ltd.
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