Abstract
Working memory (WM) is a cognitive process that involves maintaining and manipulating information for a short period of time. WM is central to many cognitive processes and declines rapidly with age. Deficits in WM are seen in older adults and in patients with dementia, schizophrenia, major depression, mild cognitive impairment, Alzheimer’s disease, etc. The frontal, parietal, and occipital cortices are significantly involved in WM processing and all brain oscillations are implicated in tackling WM tasks, particularly theta and gamma bands. The theta/gamma neural code hypothesis assumes that retained memory items are recorded via theta-nested gamma cycles. Neuronal oscillations can be manipulated by sensory, invasive- and non-invasive brain stimulations. Transcranial alternating-current stimulation (tACS) and repetitive transcranial magnetic stimulation (rTMS) are frequency-tuned non-invasive brain stimulation (NIBS) techniques that have been used to entrain endogenous oscillations in a frequency-specific manner. Compared to rTMS, tACS demonstrates superior cost, tolerability, portability, and safety profile, making it an attractive potential tool for improving cognitive performance. Although cognitive research with tACS is still in its infancy compared to rTMS, a number of studies have shown a promising WM enhancement effect, especially in the elderly and patients with cognitive deficits. This review focuses on the various methods and outcomes of tACS on WM in healthy and unhealthy human adults and highlights the established findings, unknowns, challenges, and perspectives important for translating laboratory tACS into realistic clinical settings. This will allow researchers to identify gaps in the literature and develop frequency-tuned tACS protocols with promising safety and efficacy outcomes. Therefore, research efforts in this direction should help to consider frequency-tuned tACS as a non-pharmacological tool of cognitive rehabilitation in physiological aging and patients with cognitive deficits.
Highlights
TO BRAIN OSCILLATIONS AND WORKING MEMORY Working MemoryWorking memory (WM) is a cognitive process that involves maintaining and processing information for a short period of time (Baddeley, 2012)
Among the competing models of WM: Daneman and Carpenter’s (1980) model, which showed that the capacity of WM is reflected by the reading span task and comprehensive tests; the timebased resource sharing model proposed by several researchers, which showed that the capacity of WM is a product of attention (Barrouillet et al, 2004, 2009)
Non-invasive brain stimulation, frequency-tuned stimulation, is a recent approach that relies on the entrainment of endogenous oscillations to causally alter cognition and behavior
Summary
Working memory (WM) is a cognitive process that involves maintaining and processing information for a short period of time (Baddeley, 2012). ACC acts as an “attention controller” assessing the need to adapt the information received based on task requirements
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