Abstract
Sleep is integral to life and sleep duration is important in sleep quality, physical, and psychological health. Disturbances in sleep duration have been associated with increased risk of metabolic disorders, hypertension, and overall mortality. Sleep disturbance has also been linked with various gastrointestinal disorders. However, the association between sleep and peptic ulcer disease (PUD) has not been evaluated. We investigated the association between sleep duration and PUD. Subjects were included from the fifth Korean National Health and Nutrition Examination Survey conducted from 2008–2009. Individuals with PUD were defined as those with a physician diagnosis of PUD. Daily sleep duration was established by asking participants the amount of time that they slept per day. Multiple logistic regression models were used to evaluate the association of PUD and sleep duration. This study included 14,290 participants (8,209 women). The prevalence of PUD was 5.7% and was higher in men (6.8%) than in women (4.9%). Women who slept ≥9 hours were significantly less likely to have PUD compared to women who slept 7 hours. In men, longer sleep duration (≥9 hours) had a tendency toward PUD prevention. Our results suggest that longer sleep duration may play a protective role for PUD development.
Highlights
According to a recent systematic analysis for the Global Burden of Disease study, peptic ulcer disease (PUD) is a common and serious medical problem[12,13]
The prevalence of PUD in the entire population was 5.7%, and the prevalence of PUD was higher in men (6.8%) than in women (4.9%)
There were no differences in smoking, drinking and exercise habits between those with and without PUD
Summary
According to a recent systematic analysis for the Global Burden of Disease study, PUD is a common and serious medical problem[12,13]. The prevalence of PUD is approximately 4.1%, and about 10% of people develop PUD during their lifetime[13,14]. Though Helicobacter pylori and nonsteroidal anti-inflammatory drugs are the most important risk factors for PUD, no obvious cause is found in 5–20% of PUD patients[15]. Recent studies suggest that non-organic causes such as psychological stress may play a role in the onset and course of PUD15–17. The association between sleep duration and PUD remains to be fully understood. We assessed the association between sleep duration and PUD among adults representative of the Korean population
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