Abstract
AbstractConfocal laser scanning microscope image of double immunostaining for Wfs1 protein (green) and for glial fibrillary acidic protein (GFAP; an astrocyte marker; red) in the normal mouse retina and optic nerve. Cell nuclei are labeled in blue. The Wfs1 protein, also called wolframin, is the Wolfram syndrome 1 (Wfs1) gene product. Wfs1 is the disease gene for Wolfram syndrome, a neurodegenerative disorder defined by insulin‐dependent diabetes mellitus and progressive optic atrophy. This image shows that Wfs1 immunoreactivity is observed in the GFAP‐rich part of the optic nerve immediately behind the eye (central part of the image), and in most of the retinal layers (lower part of the image). J. Comp. Neurol. 510:1–23, 2008. © 2008 Wiley‐Liss, Inc.
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