Abstract
Mitochondrial Transcription Factor A and Its Downstream Targets Are Up-regulated in a Rat HepatomaJournal of Biological ChemistryVol. 277Issue 45PreviewMitochondrial transcription factor A is a key regulator involved in mitochondrial DNA transcription and replication. In a poorly differentiated rat hepatoma, Morris hepatoma 3924A, the mRNA and protein levels of this factor were elevated about 10- and 11-fold, respectively, relative to the host liver. The mRNA levels for the hepatoma cytochrome c oxidase I, II, and NADH dehydrogenase 5, 6, the downstream targets of Tfam, were augmented 10-, 8-, 5-, and 3-fold, respectively. Interestingly, Tfam was also found in the hepatoma nucleus. Full-Text PDF Open Access VOLUME 277 (2002) PAGES 43309â43318 This article has been withdrawn by Xiaocheng Dong, Kalpana Ghoshal, Sarmila Majumder, and Samson T. Jacob. Satya P. Yadav could not be reached. The Journal questioned Figs. 1B, 1D, 2A, 4B, 5, 6A, and 6B. The withdrawing authors state that they were able to find the original data for Fig. 1B and were able to find replicate data performed at the time of the original work for Fig. 4B, which the withdrawing authors state confirm the results. The withdrawing authors stand by the reproducibility of the experimental data and the conclusions of the paper. The paper, with confirmatory data supporting the results, can be obtained by contacting the withdrawing authors.
Highlights
This article has been withdrawn by Xiaocheng Dong, Kalpana Ghoshal, Sarmila Majumder, and Samson T
The withdrawing authors state that they were able to find the original data for Fig. 1B and were able to find replicate data performed at the time of the original work for Fig. 4B, which the withdrawing authors state confirm the results
The paper, with confirmatory data supporting the results, can be obtained by contacting the withdrawing authors
Summary
This article has been withdrawn by Xiaocheng Dong, Kalpana Ghoshal, Sarmila Majumder, and Samson T.
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