Abstract
30 rabbits were turned during 30 s, and then abruptly stopped. The duration of the postrotatory nystagmus was used as parameter for the pharmacological effect. Intravenous injection of 2 mg/kg dimenhydrinate shortend the duration of postrotatory nystagmus. Contrarily 1 mg/kg thiethylperazine and 1 mg/kg dehydrobenzperidol prolonged the postrotatory nystagmus. Our experiments have shown that drugs of the same clinical effect act differently in animals. For measuring the antivertiginous effect by use of the postrotatory nystagmus criticism is indicated.
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