Abstract
These studies confirm that sequential clinical, pathologic, and biochemical changes similar to those of human osteoarthritis occur during development of a surgically induced canine osteoarthritis model. Dramatic changes were demonstrated as early as two weeks and they persisted essentially unchanged for the duration of the experiment. The most significant alterations detected were a marked decrease in total hexosamine content accompanied by increased biosynthesis of total proteins (as demonstrated by a two-fold increase in incorporation of [14C]-proline), proteoglycan (as demonstrated by an increase in incorporation of [35S]- Na2SO4) and particularly collagen (as demonstrated by a several fold increase in synthesis of [14C]-hydroxyproline). When the biosynthesized macromolecules were characterized by their extractability and electrophoretic behavior, however, no significant qualitative differences could be demonstrated and most of the changes appeared to be quantitative.
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