Abstract
COVID-19 is a life-threatening disease that mainly affects the human respiratory system. In today’s world, scientists are working conscientiously for the identification of promising drugs and vaccines. But, when we look back to the former times, herbal medicines were considered for curing most of the diseases; luckily, nowadays, natural remedies are being carried forward by few researchers even for the treatment of most life-threatening diseases like cancer, diabetes and alzheimer’s etc. So, why can't we attempt the herbal formulation for the management of COVID-19 too? Since there is no proper scientific validation for traditional herbs and spices; it just can’t be simply ignored. When a product with less or few side effects can be prepared and made available for the benefit of people, there is nothing wrong in pondering them. Thus, keeping these points in mind, in this article, we have discussed about SARS CoV-2, their treatment options and the impact of natural remedies on both the former as well as novel coronavirus. Further, we have also emphasized on traditional Chinese medicine, various flavonoids and kabasura kudineer and their impact on coronavirus infection. Till now, there is no particular drug or vaccine available for the treatment of COVID-19; thus prevention is the only option. But, we hope that thorough study; screening, preclinical and clinical evaluation of natural compounds may give some action against SARS CoV-2. Moreover, incorporating natural herbs and spices in our diet can help in boosting immunity and fight against various life-threatening diseases.
Highlights
Most of the people are being affected with the well know disease called COVID-19
When we look into the literature, the most commonly used Traditional Chinese Medicine (TCM) against SARS-CoV-2 is Qingfei paidu decoction
COVID-19 is a life-threatening disease that is affecting most of the people around the world in a contagious manner
Summary
Most of the people are being affected with the well know disease called COVID-19. Adem et al [29] have worked on natural polyphenols to identify the potent inhibitors of COVID-19 main protease with the aid of in silico modeling In this study, they have tested different flavonoids to determine their inhibitory action against the main protease of SARS-CoV-2. It was concluded that the synergistic activity of all the 17 compounds have served a good inhibition of both ACE-2 and PDB6LU7 Another in silico study has been carried out by Thirumalaisamy Rathinavel; in order to check the effect of 6-gingerol on SARS-CoV-2. In silico studies revealed that 6-gingerol had excellent drug likeliness and very good pharmacokinetic properties They have stated that it had a high binding affinity of-2.8764 KJ/mol to-15.7591 KJ/mol with multiple targets of SARS-CoV-2, including viral proteases, RNA binding protein and spike protein [32]. Keeping this particular quote in mind hope we can wisely fight against various diseases
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