Abstract
A 42-year-old Caucasian man presented with a 15-year history of a widespread, persistent, pruritic eruption over his trunk and extremities. He was not on medication and had no relevant family history. On physical examination, multiple discrete, pinkish, hyperkeratotic 1 to 2 mm papules, arranged in a rippled pattern, were detected on the trunk and extremities (Figure 1). Widespread pruritic papules on the trunk and extremities
Highlights
A 42-year-old Caucasian man presented with a 15-year history of a widespread, persistent, pruritic eruption over his trunk and extremities
An additional finding was the presence of eosinophilic, hyaline, homogeneous deposits confined to the papillary dermis, which showed metachromatic staining with crystal violet
Biphasic amyloidosis is characterized by overlap of lichen and macular amylodosis with tiny papules superimposed upon a background of hyperpigmented skin
Summary
A 42-year-old Caucasian man presented with a 15-year history of a widespread, persistent, pruritic eruption over his trunk and extremities. Multiple discrete, pinkish, hyperkeratotic 1 to 2 mm papules, arranged in a rippled pattern, were detected on the trunk and extremities (Figure 1). Generalized lichen amyloidosis On histopathological examination, epidermal changes including marked hyperkeratosis, hypergranulosis, and irregular acanthosis were observed. A diagnosis of generalized lichen amyloidosis, based on clinical and histopathological findings, was made.
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