Abstract
A correlative biochemical-neuropathological study was undertaken in order to analyze white matter gangliosides in the selective incomplete white matter infarctions (SIWI) frequently occurring in dementia of Alzheimer type. Cerebral white matter from cases with complete white matter infarcts and from control cases was analyzed for comparison. A reduction of gangliosides and changes in the ganglioside pattern reflected the histopathological degree of severity of SIWI. In the complete infarcts, the ganglioside loss and qualitative changes were further pronounced. The results of the study support the theory of SIWI being a subtotal infarction affecting both myelin and axons.
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