Abstract
A dozens of variants in intron 1 of FTO gene have been found to be significantly associated with obesity by a serious genome-wide association studies(GWAS)in past eight years. Very recently, The New England Journal of Medicine published an important genetic study of obesity, which challenged the point of FTO causing obesity directly. The researchers find one of the variants changes the binding ability of upstream regulator to IRX3/IRX5 and thus promotes IRX3/IRX5 expression instead of FTO. Which one is the real causal gene of common obesity, FTO, IRX3/5, both, or neither? All these questions need to be answered.(Chin J Endocrinol Metab, 2015, 31: 1013-1016) Key words: Obesity; Genetics; FTO; IRX3; IRX5; Genome-wide association study
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