Abstract
Cell death is an entrenched event which helps to sustain cellular homeostasis and also provides protective immunity against invading microorganisms. Cell death plays a vital role in host defense as well as the pathogenesis of microorganisms. Intracellular pathogens such as Mycobacterium tuberculosis (Mtb) manipulate cell death pathways to evade host defense mechanisms for its survival and remained as one of the deadliest infectious diseases. There has been a paradigm shift in tuberculosis (TB) research towards host-directed therapy to restrain Mtb. Studying the host-pathogen interactions in view of various cell death modalities will help us identify better strategies to fight against not only Mtb but other intracellular pathogens as well. This brief review aimed to summarize current knowledge of various cell death modalities utilized by the host and Mtb that compete with each other in the battle for survival.
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