Abstract
Background This study compared three different concentrations of EO (1.25%, 2.5% and 5%) for the treatment of oral vascular anomalies (OVAs). Material and Methods This was a retrospective comparative analysis of patients with OVAs treated with EO. Anomalies smaller than 20 mm were included. The patients were treated with 1.25% (G1), 2.5% (G2), and 5% (G3) and clinical data were obtained. The number of sessions, the final volume and dose of EO were statistically analyzed to verify effectiveness and safety of the treatment. The different concentrations of EO were compared considering the number of sessions, the final volume and total dose of EO. Analysis of covariance (ANCOVA) was used to evaluate the influence of covariates on the outcomes. A p-value < 0.05 was considered significant. Results Nineteen women and 11 men with a median age of 54 years were included. The OVAs were most frequent in the lip (n=14) and cheek (n=9). All lesions exhibited complete clinical healing within 28 days. Patients of G3 required fewer sessions than those of G2 (p=0.017), a lower final volume compared to the other groups (p<0.001), and a lower total dose than G1 (p<0.001). Patients of G1 used a lower total dose than G2 (p=0.003). Conclusions The concentration of 5% EO performed better than 1.25% and 2.5% for sclerotherapy of OVAs measuring up to 20 mm. This preliminary result should be the preferred concentration of EO to provide an effective and safe treatment of OVAs. Key words:Ethanolamine oleate, sclerotherapy, vascular malformations, hemangioma, oral mucosa.
Highlights
Sclerotherapy is an important and well-recognized treatment modality for oral vascular anomalies (OVAs)
The concentration of 5% ethanolamine oleate (EO) performed better than 1.25% and 2.5% for sclerotherapy of OVAs measuring up to 20 mm
Significant differences in the clinical diagnosis were observed between Group 1 (G1) and Group 3 (G3) (Fisher’s exact test, p=0.001), with a predominance of hemangioma cases in G1 (n=7) and of varices in G3 (n=6)
Summary
Sclerotherapy is an important and well-recognized treatment modality for oral vascular anomalies (OVAs). Previous studies have shown a good response when a concentration of 1.25%, 2.5% or 5% was used for the treatment of OVAs, but there were differences in the number of sessions and the final volume of EO necessary to achieve complete resolution [2,6,7,9]. Our hypothesis is that 5% EO is more effective and safer, requiring fewer treatment sessions and a lower final volume and total dose. This study compared three different concentrations of EO (1.25%, 2.5% and 5%) for the treatment of oral vascular anomalies (OVAs). The different concentrations of EO were compared considering the number of sessions, the final volume and total dose of EO. Patients of G3 required fewer sessions than those of G2 (p=0.017), a lower final volume compared to the other groups (p
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