Abstract
In June 1993, the Consortium of Multiple Sclerosis Centers sponsored a multidisciplinary conference in Denver, Colorado. The theoretical underpinning of the conference was a new approach to conference development, dubbed the "What Do We Know?" model. This model charges participants to evaluate what is known about MS care based on literature reviews, to ascertain how care is actually practiced, and to identify gaps in existing knowledge through this process. A significant outcome of the conference was the development of research questions and designs that will ultimately lead to multicenter clinical studies.
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