Abstract
The goal of neuroimaging techniques is to provide realistic maps of the neuronal populations that become active during particular functional tasks. Most non-invasive neuroimaging techniques (PET, fMRI, NIRS, optical imaging) measure regional cerebral blood flow or metabolism. The coupling between regional blood flow and local energy consumption was first shown by the deoxyglucose method (Sokoloff et al., 1977). How the activity related vascular and metabolic recruitment reflects the underlying synpatic processes was studied by optical reflectance methods (Grinvald et al., 1986, 1991 and their relation to electrophysiological measures (Frostig et al., 1990; Narayan et al., 1994).
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