Abstract
The (η5 -pentamethylcyclopentadienyl)cobalt(III) (Cp*CoIII )-catalyzed C-H bond functionalization of aromatic, heteroaromatic, and α,β-unsaturated Weinreb amides was explored. C-H allylation reactions with the use of allyl carbonate and a perfluoroalkene, oxidative alkenylation reactions with the use of ethyl acrylate, iodination reactions with the use of N-iodosuccinimide, and amidation reactions with the use of dioxazolones were catalyzed by Cp*Co(CO)I2 in the presence of a cationic Ag salt and AgOAc to afford various synthetically useful building blocks. Mechanistic studies of the C-H allylation disclosed that the C-H activation step was rate determining and virtually irreversible.
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