WCN26-5374 A RARE CASE OF NEPHROGENIC DIABETES INSIPIDUS IN AN ADULT MALE: A DIAGNOSTIC PROBLEM

Tuberculosis (TB) programs should design intervention strategies based on the sound knowledge of the existing local epidemiology and sociodemographic characteristics of drug-resistant-TB (DR-TB) cases. The aim of the study was to characterize the pulmonary multidrug-resistant (MDR) and rifampicin-resistant (RR) TB cases enrolled in a referral hospital at Addis Ababa, Ethiopia, called All Africa Leprosy, Tuberculosis, Rehabilitation and Training (ALERT) Hospital. We conducted a descriptive study based on retrospective review of medical records of 340 pulmonary MDR/RR-TB cases enrolled in ALERT Hospital from November 2011 to December 2016. To characterize the cases, we described the distribution of demographic and clinical characteristics. To compare the distribution of demographic and clinical characteristics between male and female cases, we used Pearson's Chi-squared test. Males accounted for 52.9% of the 340 cases. Nine out of ten cases were in the age group of 15-44 years. Sputum acid-fast bacilli smear-positive and human immunodeficiency virus-coinfected cases constituted 63.7% and 18.1% of cases, respectively. The proportion of new cases increased through the years from nil in 2011 to 21.4% in 2016. Adult males above 24 years constituted more than three quarters (77.2%) of the total male cases, while adult females in this age group constituted 56.9%. The age distribution between male and female cases showed significant differences (P < 0.001). There is age disparity between male and female cases with high impact of MDR/RR-TB on productive adult male population. The transmission potential for DR-TB is also high in the community.

Diabetes insipidus.

Diabetes insipidus in pregnancy.

Environmental influences on age and size at maturity of<i>Loligo vulgaris</i>

Background:Adult males in Sweden exhibit an increased risk of cancer associated with an increased absorbed dose to the colon from the Chernobyl accident.Methods:A closed cohort, with information on hunter status, included all individuals living in northern Sweden in 1986. Complete annual information on exposure to 137Cs at the dwelling coordinate was available for a total of 2,104,101 individuals. A nested case-control method with four controls matched for year of cancer diagnosis and year of birth, was used. Individual absorbed organ doses were calculated between 1986 and 2020 including external and internal exposure. Hazard ratios (HR) per mGy with 95% confidence intervals (95% CI) were calculated using conditional logistic regression adjusted for rural/nonrural habitat, education level and pre-Chernobyl cancer incidence 1980 to 1985. A total of 161,325 cancer cases in males and 144,439 in females were included.Results:The adjusted HR per mGy for all cancer sites combined was 1.027 (95% CI = 1.022, 1.031) in males and 1.011 (95% CI = 1.006, 1.017) in females. In a post hoc analysis accounting for both remaining confounding from hunter lifestyle and the pre-Chernobyl cancer incidence by county, the adjusted HR per mGy for all cancer sites combined was 1.014 (95% CI = 1.009, 1.019) in males and 1.000 (95% CI = 0.994, 1.006) in females. The post hoc analysis suggested an increased risk of cancer in the colon, pancreas, and stomach, respectively, in males, and lymphoma in females.Conclusions:Increased cancer risk estimates were found for some specific cancer sites but remaining uncontrolled confounding due to hunter lifestyle could not be ruled out.

Animal behaviour may change with age, when young individuals experience different environments from adults. However, the role of ontogeny in personality traits is still open to debate and it is not clear whether individual differences in behaviour are maintained across important ontogenetic changes such as metamorphosis. Here, we repeatedly quantified personality in rural and urban populations of the speckled wood butterfly (Pararge aegeria) at the larval, pupal and adult stages. We detected significant repeatability at all life stages, showing that personality is already present at the immature stages. We found no evidence for landscape-related differences in personality traits, but adult males were bolder and more active than adult females. Adults also became bolder with trial sequence, suggesting habitation to the experimental procedure. Urbanisation, together with sex, affected relationships among larval and adult personality traits. More active larvae with short latencies resulted in more explorative adults. However, this was the case in males of urban origin only, and we detected no such correlation in females or in rural males. We suggest that harsh conditions prevailing in cities may lead to stronger trait integration across metamorphosis but also that these urbanisation-related selective pressures may act differently on males and females. In many taxa, metamorphosis marks the transition between the juvenile and the adult stages. During this crucial developmental step, morphology and physiology are deeply remodelled, which may have important consequences for the behaviour of individuals. Although personality has emerged as a hot topic in behavioural ecology, little is known about the consequences of metamorphosis for personality stability. We studied rural and urban speckled wood butterflies at the immature and adult stages to examine whether insect personality is retained over metamorphosis. Sexes differed regarding boldness and activity, but rural and urban butterflies behaved similarly. Nevertheless, urbanisation affected relationships among larval and adult personality traits. Some larval and adult traits correlated in urban males, whereas this was not the case in females or in rural males. This suggests that urbanisation may alter trait combinations across metamorphosis, but this in a sex-specific manner.

In spite of a commitment to equality, the kibbutz is a male-dominated society with highly differentiated sex roles. Has this gap between ideals and reality created sex role strain for kibbutz-born adolescents and adults? Previous kibbutz studies have suggested that sex role strain may be the most intense among adult kibbutz women. Based on Erik Erikson's developmental model, however, we hypothesized that adolescent females would experience significantly greater sex role strain than other kibbutz members, including adult women. Adolescent and adult males and females were tested using Loevinger's ego development test. The sex role items of the test were used to construct a new measure of sex role strain. The global index included the following submeasures: avoidance of sex role issues; expression of intellectual, emotional, or behavioral sex role conflict; and evaluative attitudes toward male roles and female roles. Significant cohort or sex differences were found on the global index and on all submeasures of sex role strain. The findings indicate that sex role strain is greatest among adolescent females, followed by adolescent males. Adult kibbutz women, however, are significantly more likely to focus their dissatisfaction in the area of actual role behavior rather than in terms of how they intellectually conceptualize kibbutz sex roles, as is the case for adolescents and adult males.

This study measures the distribution of autistic traits, using the autism‐spectrum quotient (AQ), in siblings of individuals with autism spectrum conditions (ASC). Total AQ scores, along with AQ subscales, were collected from child, adolescent and adult controls, siblings, and volunteers with ASC using one of the three age‐appropriate versions of the instrument: the AQ (adult self‐report), the AQ‐adolescent and AQ‐child (both parent‐reports). We examined the effect of Group (case, sibling and control) and AQ version (adult, adolescent and adult) on total and subscale scores. In addition, we tested for sex differences in all groups and on all versions. We found that in male and female adults, AQ scores in siblings fell between cases and controls (cases > siblings > controls). In children and adolescents, female siblings also scored higher than control females (female cases > female siblings > female controls), but there was no difference between male siblings and controls (male cases > male siblings = male controls). An investigation of subscale scores revealed that male siblings only differed from controls on the “Communication” subscale (male cases > male siblings > male controls), while female siblings differed from controls on all subscales except “Imagination” (female cases > female siblings > female controls). This study confirms the broader autism phenotype in siblings, and reveals this is modulated by sex and AQ version. Autism Res2017, 10: 289–297. © 2016 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research.

In the Tri-State Leukemia Survey, the history of diseases in 605 adult male leukemia cases 15 years and older and in 668 adult male population controls was examined. These diseases occurred at least 1 year before leukemia was diagnosed. The data were based on respondents' answers that the disease was diagnosed by a physician; the respondent was either the subject or his spouse. Of 30 diseases studied, 7 showed an excess among the patients with leukemia: infectious hepatitis, eczema, psoriasis, diabetes, arthritis and rheumatism, heart disease, and ankylosing spondylitis. Mumps had a lower reported occurrence among the cases, whereas pneumonia was less frequent in acute lymphatic cases than in population controls. Three diseases occurred significantly less in controls than in persons with specific histologic types of leukemia. Our data revealed a more frequent history of herpes zoster (shingles) in chronic lymphatic leukemia, more hives in acute chronic myeloid cases, and meningitis in acute myeloid leukemia. When we only considered the patients' responses, more of them admitted having had acne than did our controls. The remaining diseases--childhood viral diseases, infectious mononucleosis, smallpox, typhoid fever, dysentery, scarlet fever, tuberculosis, asthma, hay fever, and goiter did not occur more frequently in cases than in controls. The findings were consistent with evidence from previous laboratory and clinical studies. The increased occurrence of infectious hepatitis in our case series is consistent with the findings of other studies showing an increased frequency of Australia antigen in patients with hepatitis, leukemia, and Down's syndrome.

The evidence on the carcinogenicity of tobacco smoking has been well established. An assessment of the population-attributable fraction (PAF) of cancer due to smoking is needed for France, given its high smoking prevalence. We extracted age- and sex-specific national estimates of population and cancer incidence for France, and incidence rates of lung cancer among never smokers and relative risk (RR) estimates of smoking for various cancers from the American Cancer Prevention Study (CPS II). For active smoking, we applied a modified indirect method to estimate the PAF for lung and other tobacco smoking-related cancer sites. Using the RR estimates for second-hand smoking, the proportion of never smokers living with an ever-smoking partner derived from survey, and marital status data, we then estimated the PAF for lung cancer attributable to domestic passive smoking. Overall in France in 2015, 54 142 and 12 008 cancer cases in males and females, respectively, were attributable to active smoking, accounting for 28 and 8% of all cancer cases observed among adult (30+ years) males and females. Additionally, 36 and 142 lung cancer cases, respectively among male and female never smokers, were attributable to second-hand smoke resulting from their partner's active smoking, corresponding to 4.2 and 6.7% of lung cancer cases which occurred in never smoker males and females, respectively. Tobacco smoking is responsible for a significant number of potentially avoidable cancer cases in France in 2015. More effective tobacco control programmes are critical to reduce this cancer burden.

The aim of this study was to estimate the incidence of tuberculous meningitis in the State of Santa Catarina (SC), Brazil, during the period from 2001 to 2010. Ecological, temporal, and descriptive methods were employed using data obtained from the Information System on Disease Notification (Sistema de Informação de Agravos de Notificação). One hundred sixteen reported cases of tuberculous meningitis occurred from 2001 to 2010, corresponding to 1.2% (0.2 cases/100,000 inhabitants) of all meningitis cases reported in SC. There was a predominance of new cases in males, corresponding to 56.9% of new cases (0.2 cases/100,000 inhabitants; males vs. females; p=0.374), in patients aged 20-39 years, corresponding to 52.6% of new cases (0.5 cases/100,000 inhabitants; 20-39 years versus others; p<0.001), and in urban areas, corresponding to 91.4% of new cases (0.2 cases/100,000 inhabitants; urban vs. rural; p=0.003). In 48.3% of cases, the outcome was death. The incidence rate of tuberculous meningitis in SC has increased within the last decade, with the most affected population comprising young adult white males with an average education. Thus, tuberculous meningitis remains a serious disease, emphasizing the need for disease prevention with vaccination campaigns against tuberculosis, the development of faster and more accurate diagnostic methods, and the use of current epidemiological knowledge regarding the disease to facilitate the establishment of early treatment.

This case study highlights the important contribution of nursing in obtaining an accurate health history. The case discussed herein initially appeared to be neurogenic diabetes insipidus (DI) secondary to a traumatic brain injury. The nursing staff, by reviewing the patient's health history with his family, discovered a history of polydipsia and long-standing lithium use. Lithium is implicated in drug-induced nephrogenic DI, and because the patient had not received lithium since being admitted to the hospital, his treatment changed to focus on nephrogenic DI. By combining information from the patient history, the physical examination, and radiologic and laboratory studies, the critical care team demonstrated that the patient had been self-treating his lithium-induced nephrogenic DI and developed neurogenic DI secondary to brain trauma. Thus successful treatment required that nephrogenic and neurogenic DI be treated concomitantly.

Given the rapidly changing media landscape and popularity of e-cigarettes among young adults who identify as lesbian or gay, bisexual, questioning, or something else (LGB+), timely data on media consumption and exposure to e-cigarette content across media channels is imperative for developing counter-messaging and public education campaigns for these individuals. Using 2023 data from young adults in California, this study examined how social media use differed for heterosexual and LGB + young adults, by sex. Exposure to e-cigarette content across media channels was also compared between heterosexual and LGB + young adults, by sex. Findings from a non-probability representative sample of young adults in California showed that more LGB + young adults reported using Tumblr and fewer reported using Facebook and Snapchat, compared with heterosexual young adults, among both males and females. Use of Reddit was more common among LGB + versus heterosexual females, but there were no differences in sexual identity among males. Exposure to e-cigarette marketing was more common among LGB + females compared with heterosexual females, but this was not the case for males. Exposure to user-generated e-cigarette content, and self-reported visits to e-cigarette websites, were more common among LGB + females compared to heterosexual females. These findings highlight the importance of treating LGB + individuals as a heterogeneous group. As such, anti-tobacco campaigns targeting LGB + individuals that leverage social media will want to consider which platforms are most used among their target audience to increase campaign reach. This study builds upon the literature by providing timely data on how LGB + young adults consume social media and are exposed to e-cigarette marketing. Findings have implications for tobacco education campaigns designed for LGB + individuals that leverage social media.

After 15 males invaded troops of wild red howler monkeys (Alouatta seniculus) present in Venezuela during the period from Apr. 1989 to May 1991, five infant killings and eight infant disappearances occurred. Among the eight groups that were invaded, 10 infants of less than 3 mo old and three of over 5 mo old were killed either by the adult or subadult males, or disappeared. However, on the five occasions of invasion, none of the nine infants were killed. In two other groups, there were no infants present at the time of invasion. It was also noted that no infant of kin of the invading males was killed. At least six of the females that had lost their infant during such invasion subsequently copulated both with the invader as with the original resident male. In one case, a female copulated with the resident male of a neighbouring group. In the four cases of subadult males committing infanticide there was no immediate sexual access to the females. The data presented here are inconsistent with the reproductive sexual‐advantage hypothesis, but consistent with the hypothesis concerning food competition.

Fungal keratitis is a destructive ocular infection, representing a serious diagnostic and therapeutic problem, difficult to treat and with poor results. It can cause irreversible damage. Keratomycoses are rare and may be under-diagnosed. Direct microscopic examination and culture are essential for early specific diagnosis and must be taken into consideration to establish the most effective treatment and avoid serious complications. The pathogenesis of this infection is based on three factors: colonization, tissue damage and immunosuppression. We report 2 cases of Fusarium oxysporum keratomycosis treated with amphotericin B. The diagnosis of corneal abscess was made after ophthalmological examination in 2 adult males with no previous ophthalmological history, referred to the Omar Drissi hospital in Fez for decreased visual acuity, photophobia, redness and intense pain in the right/left eye. Corneal scrapings were taken for microbiological analysis, and after initial mycological results, local and systemic antifungal treatment was initiated with amphotericin B and natamycin eye drops. The evolution was marked by a corneal perforation with a tenon patch graft for the first patient, and healing for the 2nd