Abstract
This article will briefly overview our efforts in the engineering of water soluble variants of a G-protein coupled receptor (GPCR) and its novel applications to develop biosensors using such water soluble variants of GPCR. While the technologies using water soluble GPCR are still under development, they offer new tools and strategies to study the function of GPCR, explore potential new compounds for potential clinical usage, and monitor endogenous peptides in various physiological and pathological conditions.
Highlights
This article will briefly overview our efforts in the engineering of water soluble variants of a G-protein coupled receptor (GPCR)
Many medications used in perioperative and pain medicine target GPCRs. These include beta-adrenergic receptors, dopamine receptors, vasopressin receptors, and opioid receptors as well as many others
It is thought that both the analgesic and side effects are transduced through the mu opioid receptor (MOR) [13,16]
Summary
This article will briefly overview our efforts in the engineering of water soluble variants of a G-protein coupled receptor (GPCR). The information derived from this specific receptor can potentially be applicable to other GPCRs. Our multi-disciplinary team has been working on developing novel approaches to study ligand and receptor interactions with a specific focus on MOR [4,6,17,18,19,20].
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