Abstract
AbstractGadolinium oxide (Gd2O3) nanoplates have been successfully synthesized by thermal decomposition method in the presence of oleic acid and oleylamine as surfactants. As a result, the nanoplates have average edge length and thickness around 10 nm and 1.1 nm, respectively. The hydrophobic OA/OM capped Gd2O3 nanoplates were encapsulated with amphiphilic poly (maleic anhydride‐alt‐1‐octadecene) polymer (PMAO) for phase transfer into aqueous media. The obtained Gd2O3@PMAO showed a hydrodynamic size of 32 nm with good dispersion in water solvent and stable in wide range of pH (pH=2÷11) and at electrolyte concentrations as high as NaCl 380 mM. In addition, the in vitro toxicity tests confirmed the biocompatibility of Gd2O3@PMAO nanoplates. The magnetic resonance imaging (MRI) result exhibited the r1 of Gd2O3@PMAO nanoplates (16.95 mM−1s−1) is four times higher than that of clinically used Gd‐DTPA. These results suggest that the PMAO coated ‐Gd2O3 nanoplates are potential T1 contrast agents for in vivo MRI application.
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