Abstract
BackgroundThe metabolic syndrome (MetS) is associated with the presence of low grade inflammation. Our aim was to analyze the inter-relations between each of the components of the metabolic syndrome (MetS) and four inflammatory markers, namely high sensitivity C-reactive protein (hs-CRP), the erythrocyte sedimentation rate, the concentration of fibrinogen and the white blood cell count.MethodsWe have analyzed data collected between September 2002 and June 2009 in the Tel-Aviv medical center inflammation survey (TAMCIS). We recruited both apparently healthy individuals and individuals presenting with atherothrombotic risk factors. All participants were enrolled during their routine annual health check-up and gave their written informed consent. This is a cross sectional study in which we have fitted linear regression models using inflammatory markers as the dependant variables and adjust them according to the different components of the MetS and multiple other confounders.ResultsIncluded were 12,072 individuals of whom there were 7,760 men at a mean (S.D.) age of 44 (11) years, and 4,312 women aged 44 (11) years. A significant correlation was noted between most components of the MetS and all inflammatory markers, the most significant one being with hs-CRP. In the multi-adjusted regression analysis, waist was the factor that best explained the variability of hs-CRP, in both women and men. It also remained a significant variable for the other inflammatory markers.ConclusionsFrom amongst the various components of the MetS, waist circumference appears to exert the most influence upon the presence and intensity of the micro-inflammatory response.
Highlights
The metabolic syndrome (MetS) is associated with the presence of low grade inflammation
In order to evaluate the contribution of the MetS components to the microinflammatory process, this cross sectional study has analyzed the strength of the association between each MetS component and four established inflammatory markers
Subjects attending the center for a routine health examination between September 2002 and June 2009 were invited to participate in the Tel-Aviv medical center inflammation survey (TAMCIS)
Summary
The metabolic syndrome (MetS) is associated with the presence of low grade inflammation. The metabolic syndrome (MetS) is associated with the presence of a low grade sub-clinical inflammatory process, so called micro-inflammation [1,2,3,4,5,6,7]. The relationship between this process and the risk of insulin resistance development, a hallmark of the MetS,[7,8,9] as well as the risk of cardiovascular morbidity and mortality, [10,11,12] has been previously described. The relative influence of the components of the MetS on these inflammatory markers may be of clinical significance aiding in the establishment of clinical guidelines for health care providers as well to public health policy makers
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