Abstract
Crohn's disease (CD) is a chronic inflammatory bowel disease with polymorphous cutaneous manifestations. Vulvar localization is rare and may be either isolated, revealing the disease, or associated with digestive manifestations. Treatment is difficult and not well codified. Based on 4 case reports of vulvo-perineal involvement, we present a reminder of the diagnostic and therapeutic challenges of this particular site. In 2 out of 4 patients, vulvar involvement was incipient, with no gastrointestinal symptoms at the time of diagnosis. The vulva may present with many dermatological manifestations: knife-like ulcerations, oedema, labial hypertrophy, lymphangiectasia, abscesses and fistulae. The presence of non-caseating granulomas on histology may help to confirm the diagnosis. Vulvar CD affects quality of life and requires long-term medical and surgical management with a multidisciplinary approach involving gastroenterologists, dermatologists, gynecologists and pathologists.
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