Pediatria. Journal named after G.N. Speransky | VOL. 101
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ВРОЖДЕННАЯ НЕЙРОБЛАСТОМА: ОБЗОР ЛИТЕРАТУРЫ И СОБСТВЕННЫЙ ОПЫТ НМИЦ ДГОИ им. ДМИТРИЯ РОГАЧЕВА ПО ПРЕНАТАЛЬНОЙ ДИАГНОСТИКЕ, КЛИНИЧЕСКОМУ ТЕЧЕНИЮ И ТАКТИКЕ ВЕДЕНИЯ ПАЦИЕНТОВ

Publication Date Jun 17, 2022

Abstract

Congenital neuroblastoma (NB) accounts for 5 % of the total number of patients with this diagnosis and is characterized by a favorable remote prognosis. Most patients are stratified into a low-risk group and do not need chemotherapy. However, in some cases, at stage 4S the disease may develop life-threatening symptoms. Objective of the study: development of an algorithm for prenatal diagnosis and management of patients after birth with NB diagnosis. Materials and methods of research: the study includes 29 patients with a diagnosis of «neuroblastoma», first suspected during ultrasound of the fetus. Therapy and dynamic observation were carried out at the National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev (Moscow, Russia) from January 2012 to July 2021 (115 months). The stage of the disease was established in accordance with international criteria (G.M. Brodeur, 1993). Stratification for risk groups and therapy was carried out according to the recommendations of the modified protocol of the German group for the treatment of NB-2004. Results: the median of the gestation period at the time of detection of pathological changes in the fetus in 25 cases was 36 weeks (spread 28–40 weeks). In 4 patients, the exact period of detection of prenatal formation was not specified in medical documents. The most frequently detected pathology was interpreted as a voluminous formation of retroperitoneal space – 20/29 (70%) cases, in 7/29 (24%) – as the formation of the abdominal...

Concepts

Stage Ofthe Disease Management Of Patients Detection Of Pathological Changes Neuroblastoma Dmitry Rogachev Intermediate Risk Group Detection Of Pathologies National Scientific 4th Stage Algorithm For Management Of Patients

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