Abstract
Elasmobranchs maintain a high concentration of NaCl in their extracellular fluid, which is matched intracellularly by organic solutes such as β-amino acids. Hypo-osmotic stress causes a volume regulatory response involving an increased efflux of β-amino acids. The mechanism of transmembrane signaling involved in this response is under investigation in skate RBC. The effects of hypo-osmotic stress on taurine efflux are mimicked by activating protein kinase C with phorbol ester or elevated cellular Ca+2. Hypo-osmotic stress induces an immediate elevation in cellular production of the protein kinase C activator diacylglycerol. These results suggest that activation of protein kinase C is involved in the volume regulatory response of skate RBC to hypoosmotic stress.
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