Abstract
This is a secondary exploratory analysis of a previously organized nationwide retrospective observational study in Japan (JGOG-1075S). This nationwide study examined consecutive 1,061 women with stage I-IV vulvar cancer, who received primary treatment care at 109 JGOG-affiliated centers from 2001-2010. The primary objective of analysis was to examine the association between hospital treatment volume of vulvar cancer and survival outcome. For the exposure allocation, hospital treatment volume over the 10-year study period was collected for any treatment modality that involved primary therapy after the vulvar cancer diagnosis. For the outcome measures of survival endpoint, progression-free survival and overall survival were assessed. Cox proportional-hazard regression models with restricted cubic spline transformation were fitted for analysis.
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