Abstract
Standard models of voltage sensing in voltage-sensitive ion channels assume rigidity in gates and other everyday devices, but if rigidity requires the cooperation of numerous strong interatomic bonds, can it exist in a macromolecule at physiological temperature? Can an ion channel be pierced by a water-filled pore without suffering electrical breakdown? The Channel Activation by Electrostatic Repulsion (CAbER) hypothesis proposes that threshold reduction of the electric field magnitude across the excitable channel allows thermal disorder to overcome a partial order of electric dipoles induced by the high resting field.
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