Abstract
PurposeTo measure vitreous levels of Lipocalin2 (LCN2) in patients with rhegmatogenous retinal detachment (RRD) and investigate potential association with presence of proliferative vitreoretinopathy (PVR).Materials and methodsCollection of undiluted vitreous samples from 24 patients suffering from RRD and 10 control patients undergoing vitrectomy for: vitreomacular traction (VMT) (n = 2), idiopathic epiretinal membrane (iERM) (n = 6) and full thickness macular hole (FTMH) (n = 2). Quantitative analysis of LCN2 has been made with flow cytometry. Lens status, duration of symptoms, quadrants of detachment, as well as level of PVR, were assessed. Statistical analysis included Mann-Whitney test, Kruskal-Wallis test, t-test, Spearman’s correlation coefficient and Fisher's exact test.ResultsMedian LCN2 was significantly higher in the RRD group as compared to control (p<0.001). Within the RRD group there was a positive correlation between LCN2 and PVR grade (rs = 0.94, p<0.001). Median LCN2 was 35,759 pg/ml (IR = 55,347) in grade C PVR, 9,387 pg/ml (IR = 3721) in grade B, 4,917 pg/ml (IR = non computable) in grade A and 3,921 pg/ml (2132) in the no PVR group. Median LCN2 was also significantly higher in pseudophakic patients as compared to phakic patients (p = 0.007). LCN2 also correlates with the extend of detachment (≤2 vs >2 quadrants, p<0.001) as well as with duration of symptoms (rs = 0.87, p<0.001). After multivariate linear regression analysis, only PVR was independently related with LCN2 concentration. In particular, increased PVR grading was associated with increased LCN2 concentration (coefficient b = 2.97, 95% confidence interval = 1.89 to 4.67, p<0.001).ConclusionA positive correlation between vitreous levels of LCN2 and PVR grading reveals a potential role in the pathogenesis and progression of PVR. Further studies could elucidate if LCN2 could be a therapeutic target.
Highlights
Nowadays, single operation success rate in the management of retinal detachment is approximately 80% [1,2,3,4]
Collection of undiluted vitreous samples from 24 patients suffering from rhegmatogenous retina detachment (RRD) and 10 control patients undergoing vitrectomy for: vitreomacular traction (VMT) (n = 2), idiopathic epiretinal membrane (n = 6) and full thickness macular hole (FTMH) (n = 2)
Median LCN2 was significantly higher in the RRD group as compared to control (p
Summary
Single operation success rate in the management of retinal detachment is approximately 80% [1,2,3,4]. Nearly 10% of patients will need repeat surgery due to the risk of recurrence [5] mostly from Proliferative Vitreoretinopathy (PVR), which remains an unsolved problem for patients and vitreoretinal surgeons. As a result of the aforementioned as well as additional alterations [6, 7], retina traction with subsequent contraction ensue. It occurs in 5–10% of rhegmatogenous retina detachment (RRD) cases, and in 75% of re-detachments after a successful surgical repair [8]. Various studies and clinical trials for the pharmaceutical treatment or prevention of PVR have been performed [15]; yet the standard treatment remains surgical [16]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
