Abstract
To study the efficacy of parenteral vitamin E in minimizing neonatal hyperbilirubinemia in both G6PD deficient and normal term infants, a prospective controlled study was performed. Parenteral vitamin E, 20 units/Kg/day for 4 days, was administered from birth. No significant difference in gestational age, nor birth weight between Group A (G6PD-Rx), Group B (G6PD-no Rx), Group C (Normal-Rx) nor Group D (Normal-No Rx) were noted. Mean peak bilirubin was:Similarly the percentage of infants requiring phototherapy or exchange transfusion did not differ significantly. No complications from vitamin E therapy were noted.Thus parenteral prophylactic vitamin E was not efficacious in minimizing either neonatal physiologic hyperbilirubinemia or neonatal jaundice associated with G6PD deficiency in Israeli subjects. Noteworthy also is the lack of excessive hyperbilirubinemia in G6PD deficient compared to normal subjects in this study population.
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