Abstract
ABSTRACT Vitamin C (VC) is an essential micronutrient and plays important roles in various biological processes including immune responses. Vaccination can stimulate immune responses effectively for prevention of virual infection. Adequate VC intake is required for the immune system to function efficiently. In this study, we evaluated the biological function of VC on immune response to inactivated foot-and-mouth disease (FMD) vaccine. The C57BL/6 mice were injected intraperitoneally with different dose of VC daily following immunization with inactivated FMD vaccine. The results showed high dose of VC supplementation significantly increased IgG level. Similarly, high dose of VC supplementation enhanced Th2 and Th17 cellular immune responses and also increased MHCII expression on dendritic cells. Taken together, these data indicate that high dose of VC supplementation can modulate Th2 and Th17 cellular immune responses to inactivated FMD vaccine and manifest the necessity for effective vaccination.
Highlights
Vitamin C (VC) is an essential nutrient required for normal physiological functions in the body
We revealed the effects of VC supplementation on immune responses to an inactivated foot-and-mouth disease (FMD) vaccine in C57BL/6 mice
The results showed that C57BL/6 mice treated with 10 mg VC had improved antigen presentation of dendritic cells (DCs), which elicited antigen-specific humoral and Th2/Th17 cellular immune responses
Summary
Vitamin C (VC) is an essential nutrient required for normal physiological functions in the body It is necessary for the health of humans, animals and cells. High doses of VC (100 mg/kg body weight) increased the efficiency of immunization with a human cell culture rabies vaccine in guinea pigs (Banic, 1982). VC increased production of interferon-α/β (IFN) and induced in vivo antiviral immune responses at the early stage of influenza virus infection in L-gulonoγ-lactone oxidase knockout (Gulo-/-) mice (Kim et al, 2013). These findings indicated different effects of VC on immune cells and responses according to the dosage, route of administration and animal species. VC injection was applied in this study for accurate doses of VC supplementation
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