Abstract
SummaryControl and hypothalamic-hyperphagic rats were injected daily with pyridoxine hydrochloride at dosage levels of 10, 40, 80, 120, 160, and 200 μg/day for 32 days. Body weights and food intakes were measured throughout the experimental period; erythrocyte glutamic-pyruvic transaminase activities (GPT) were measured at the termination of the experiment. Based on body weight changes, it is suggested that vitamin B6 requirement is in the range 80-120 μg/day for both control and hyperphagic rats. However, a daily dose of at least 200 μg is required to elicit maximum erythrocyte GPT activity. A significant correlation between vitamin intake and enzyme activity was observed thus indicating a direct relationship. There appeared to be no evidence of an increased requirement for vitamin B6 as a consequence of hyperphagia and therefore, it is concluded that in the rat, requirement for this vitamin is not related to calorie intake.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
