Abstract
The development of antibiotic-resistant strains of bacteria depends on a dynamic growth process, involving a program that is far more complex than mere emergence of mutants with higher resistance than their predecessor strains, according to Roy Kishony of Technion-Israel Institute of Technology in Haifa and Harvard Medical School in Boston, Mass., and his collaborators. This conclusion is based on viewing how cells change while growing on “microbial evolution and growth arena (MEGA)” plates, following those cells as they spread along large plates containing antibiotics as well as nutrients. Details appeared 9 September 2016 in Science (doi:10.1126/science.aag0822).
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