Abstract
Neural activity during vertebrate development has been unambiguously shown to play a critical role in sculpting circuit formation and function. Patterned neural activity in various parts of the developing nervous system is thought to modulate neurite outgrowth, axon targeting, and synapse refinement. The nature and role of patterned neural activity during development has been classically studied with in vitro preparations using pharmacological manipulations. In this review we discuss newly available and developing molecular–genetic tools for the visualization and manipulation of neural activity patterns specifically during development.
Highlights
MOLECULAR NEUROSCIENCEVisualization and manipulation of neural activity in the developing vertebrate nervous system
Neural circuits are assembled with a high degree of precision and stereotypy in the developing brain
Given the many advances made in optical imaging and molecular genetics methodologies for systems neuroscience, we discuss here some of the technologies available to developmental neurobiologists for recording from neuronal populations optically during neural circuit formation
Summary
Visualization and manipulation of neural activity in the developing vertebrate nervous system. Max Delbrück Center for Molecular Medicine, Germany. Reviewed by: Peer Wulff, University of Aberdeen, UK Ye He, University of California San Francisco, USA. Neural activity during vertebrate development has been unambiguously shown to play a critical role in sculpting circuit formation and function. Patterned neural activity in various parts of the developing nervous system is thought to modulate neurite outgrowth, axon targeting, and synapse refinement. The nature and role of patterned neural activity during development has been classically studied with in vitro preparations using pharmacological manipulations. In this review we discuss newly available and developing molecular–genetic tools for the visualization and manipulation of neural activity patterns during development
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