Viscosimetric investigation of the interaction between sodium dodecylsulfate micelles and a polymer drug carrier

Abstract

The viscosities of aqueous sodium dodecyl sulfate solutions with and without α,β-poly( N-hydroxyethyl)- dl-aspartamide (PHEA), at 15, 25 and 35°C are reported. The viscosities of SDS and of PHEA aqueous solutions are discussed in terms of the parameter D [D = ( η η 0 − 1)/φ] describing the non-ideal behavior of SDS micelles and of PHEA macromolecules. The viscosities of SDS plus PHEA aqueous solutions, discussed in terms of the parameter F [ F = η rel ( PHEA) + η rel ( SDS) − η rel ( SDS + PHEA)] M, demonstrate the occurrence of interactions between SDS micelles and the PHEA macromolecule. Both D and F are scarcely influenced by temperature variation.