Abstract
Suckling mice developed encephalitis after intracerebral inoculation of a mouse-adapted strain of human measles virus. Histologically, the necrotic foci originated around the site of inoculation, but later widespread involvement of the brain was noted. Assays for cell-associated infectious virus yielded evidence of viral replication in the brain: an initial disappearance of infectivity was followed by a logarithmic rise in virus titer. Neither cell-free infectious virus nor mature virus particles in infected brain cells were detected. Cytoplasmic tubular structures were observed by electron microscopy, usually within severely damaged brain cells. These tubular structures (110–150 Å in diameter) were probably viral nucleocapsids. Further support of this was the ease with which the nucleocapsids could be detected by negative staining procedures in grossly obvious brain lesions. The results indicate that measles encephalitis in the mouse results from direct viral invasion and multiplication of the virus in brain cells.
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