Abstract
Background. Morphological changes of erythroid progenitor cells have suggested virus infection in pediatric patients with congenital anemia. However, the available information of viral origin is limited. In this study we investigated the relationship of erythrovirus B19 (EVB19), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) with congenital anemia in Taiwanese pediatric patients. Methods. The existence of EVBI9, EBV and CMV was determined by polymerase chain reaction. The presence of EVB19 in the specific cell type was characterized by immunocytochemistry (IMC) Results. The presence of EVB19 was determined in seven patients with congenital anemia (100%). Expression of VP-2 was detected in the erythroblasts of the bone marrow by IMC. However, expression of EBV-encoded protein was identified in three patients who had symptoms of infectious mononucleosis and CMV-encoded protein was identified in one patient with severe pancytopenia. Conclusions. These results indicate that the congenital anemia and morphological changes in erythroid progenitor cells are associated with EVB19 infection. Nonetheless, the induction mechanism of congenital anemia with EVB19 infection has yet to be determined.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
