Abstract
Most studies looking at the reversal of drug resistance in hematological malignancies have focused on the blockade of P-glycoprotein (Pgp) pump activity, as one of the more important proteins involved in cell resistance to the chemotherapeutic agents used. In model experiments using the IM-9 lymphoblastoid cell line cultured with increasing doses of vincristine (Vcr) in the presence or absence of the Pgp blocker cyclosporin A (CsA) we established two Vcr resistant sublines. By measuring Pgp expression in target cells, and the activity and sensitivity to cytostatics we believe that our results suggest the presence of other mechanisms involved in cell resistance to xenobiotics and that these mechanisms should be considered in the development of clinical trials designed to overcome drug resistance.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
