Abstract
This study was conducted to experimentally determine whether a Vibrio vulnificus quorum sensing (QS) system actually operates ex vivo. The expressions of luxS encoding autoinducer-2 synthase, of smcR encoding the master regulator of QS system, and of vvpE encoding a metalloprotease, the best known target directly regulated by QS, were increased with increasing bacterial density in cirrhotic ascites used as a human ex vivo experimental system. A luxS or smcR mutation significantly decreased vvpE expression under the same conditions. Accordingly, V. vulnificus QSS is likely to operate ex vivo.
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