Abstract
Pregnant rats subjected to very mild stress give birth to pups who, when examined as adults, exhibited behavioral and anatomical anomalies that resemble some aspects of schizophrenia. The nucleus accumbens (NAcc) is reduced in volume by 20.7 +/- 3.4% (p = 0.003) in pups born to mothers who were stressed during pregnancy by injections of either saline or amphetamine in saline. The total number of cells is decreased in proportion to the reduction in volume, so the volume cell density of the NAcc is not changed with treatment. The affected volume is localized in the ventral rostral area of the NAcc. Both males and females are affected, but males are slightly more sensitive to the challenge to the mother. Rats born to mothers stressed in mid-pregnancy appear to provide useful parallels to the fetal developmental hypothesis of schizophrenia and to the brain abnormalities seen in this disease.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
